Synthesis, Antitumor and Anti-inflammatory Activities of 2-thienyl-3-substitued Indole Derivatives

A series of 2-thienyl-3-substitued indole derivatives (1-11) were synthesized. Their structures were established on the basis of elemental and spectral (IR, HNMR and Mass spectral data) studies. All the 1 synthesized compounds have been tested for their antitumor activity against breast cancer cell line (MCF-7) using doxorubicin as a standard drug (IC =2.97 μg/ml). Most of the prepared compounds showed good to 50 moderate antitumor activity. The most potent one was 10b ( IC =2.6 μg/ml). Twelve of the prepared compounds 50 were evaluated for their anti-inflammatory activity (against carrageenan induced oedema in albino rats at a dose of 50 mg/kg body weight using indomethacin at a dose of 25mg/kg body weight as a standard drug) and ulcerogenic effect. Compound 9a exhibited 55.31% inhibition with ulcerogenic activity less than that of indomethacin.